InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP51A1

Summary

InnateDB Gene

IDBG-26219.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP51A1

Gene Name

cytochrome P450, family 51, subfamily A, polypeptide 1

Synonyms

CP51; CYP51; CYPL1; LDM; P450-14DM; P450L1

Species

Homo sapiens

Ensembl Gene

ENSG00000001630

Encoded Proteins

IDBP-26221

cytochrome P450, family 51, subfamily A, polypeptide 1

IDBP-381597

cytochrome P450, family 51, subfamily A, polypeptide 1

IDBP-381601

cytochrome P450, family 51, subfamily A, polypeptide 1

IDBP-381603

cytochrome P450, family 51, subfamily A, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:92112151-92142952

Strand

Reverse strand

Band

q21.2

Transcripts

ENST00000003100	ENSP00000003100
ENST00000450723	ENSP00000406757
ENST00000422867	ENSP00000394268
ENST00000435873	ENSP00000412536
ENST00000482924

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	2 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008398	sterol 14-demethylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0016125	sterol metabolic process
GO:0033488	cholesterol biosynthetic process via 24,25-dihydrolanosterol
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070988	demethylation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle