InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fancl

Summary

InnateDB Protein

IDBP-262238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fancl

Protein Name

Fanconi anemia, complementation group L

Synonyms

2010322C19Rik; AW554273; B230118H11Rik; gcd; Phf9; Pog;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105135

InnateDB Gene

IDBG-156079 (Fancl)

Protein Structure

UniProt Annotation

Function

Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. {ECO:0000269PubMed:12417526, ECO:0000269PubMed:12606378}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21229326}. Nucleus {ECO:0000269PubMed:21229326}. Note=In the nucleus, colocalizes with UBE2W.

Disease Associations

Note=Defects in Fancl are a cause of the gcd (germ cell deficient) mutant phenotype, which leads to reduced numbers of precursor germ cells and adult sterility, probably due to a reduced precursor germ cells proliferation.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006281	DNA repair
GO:0006513	protein monoubiquitination
GO:0006974	cellular response to DNA damage stimulus
GO:0007276	gamete generation
GO:0042127	regulation of cell proliferation