Mus musculus Protein: Bpi | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-262255.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Bpi | ||||||||||||
Protein Name | bactericidal permeablility increasing protein | ||||||||||||
Synonyms | |||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Protein | ENSMUSP00000105126 | ||||||||||||
InnateDB Gene | IDBG-211473 (Bpi) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. {ECO:0000269PubMed:15590754}. | ||||||||||||
Subcellular Localization | Secreted {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000269PubMed:15590754}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | Expressed in testis, epididymis, and bone marrow, as well as in Sertoli and promyelocytic cell lines. Upon stimulation with different TLR ligands, it is strongly expressed in granulocytes and in bone marrow-derived dendritic cells. {ECO:0000269PubMed:15590754, ECO:0000269PubMed:16365446}. | ||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | MGI:3045315 | ||||||||||||
InterPro |
IPR001124
Lipid-binding serum glycoprotein, C-terminal IPR017942 Lipid-binding serum glycoprotein, N-terminal IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain |
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PFAM |
PF02886
PF01273 |
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PRINTS | |||||||||||||
PIRSF | |||||||||||||
SMART |
SM00329
SM00328 |
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TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q67E05 | ||||||||||||
PhosphoSite | PhosphoSite-Q67E05 | ||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 329547 | ||||||||||||
UniGene | Mm.260883 | ||||||||||||
RefSeq | |||||||||||||
MGI ID | |||||||||||||
MGI Symbol | Bpi | ||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | AK033770 AL663063 AY363993 AY648037 AY853179 BC118049 BC118504 | ||||||||||||
GenPept | AAI18050 AAI18505 AAR13289 AAV65841 AAW50819 BAC28468 CAM23524 CAM23525 CAM23526 | ||||||||||||