InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bpi

Summary

InnateDB Protein

IDBP-262257.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bpi

Protein Name

bactericidal permeablility increasing protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105125

InnateDB Gene

IDBG-211473 (Bpi)

Protein Structure

UniProt Annotation

Function

The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. {ECO:0000269PubMed:15590754}.

Subcellular Localization

Secreted {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000269PubMed:15590754}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.

Disease Associations

Tissue Specificity

Expressed in testis, epididymis, and bone marrow, as well as in Sertoli and promyelocytic cell lines. Upon stimulation with different TLR ligands, it is strongly expressed in granulocytes and in bone marrow-derived dendritic cells. {ECO:0000269PubMed:15590754, ECO:0000269PubMed:16365446}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0008289	lipid binding

Biological Process

GO:0006955	immune response
GO:0032715	negative regulation of interleukin-6 production
GO:0032717	negative regulation of interleukin-8 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0042742	defense response to bacterium
GO:0043031	negative regulation of macrophage activation

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:3045315

InterPro

IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain

PFAM

PF02886
PF01273

PRINTS

PIRSF

SMART

SM00329
SM00328

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q67E05