InnateDB Protein
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IDBP-262488.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cbfb
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Protein Name
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core binding factor beta
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Synonyms
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AI893578; PEA2; Pebp2; PEBP2b; Pebpb2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000105021
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InnateDB Gene
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IDBG-186824 (Cbfb)
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Protein Structure
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Function |
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues tested. Highest level in thymus, but also abundantly expressed in muscle, lung and brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
|
Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
25 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:99851
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InterPro |
IPR003417
Core binding factor, beta subunit
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PFAM |
PF02312
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q08024
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PhosphoSite |
PhosphoSite-Q08024
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
12400
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UniGene |
Mm.399600
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RefSeq |
NP_001154928
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MGI ID |
2JHB
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MGI Symbol |
Cbfb
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OMIM |
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CCDS |
CCDS52656
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HPRD |
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IMGT |
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EMBL |
AK089094
BC006763
BC026749
BC040752
D14569
D14570
D14571
D14572
L03279
L03305
L03306
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GenPept |
AAH06763
AAH26749
AAH40752
BAA03423
BAA03424
BAA03425
BAA03426
BAC40748
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