InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGAL

Summary

InnateDB Protein

IDBP-26262.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGAL

Protein Name

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

Synonyms

CD11A; LFA-1; LFA1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000349252

InnateDB Gene

IDBG-26260 (ITGAL)

Protein Structure

UniProt Annotation

Function

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0016337	single organismal cell-cell adhesion
GO:0022407	regulation of cell-cell adhesion
GO:0022409	positive regulation of cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0042102	positive regulation of T cell proliferation
GO:0050776	regulation of immune response
GO:0050798	activated T cell proliferation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050900	leukocyte migration

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF00092
PF01839
PF14312
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00327
SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt