InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGAL

Summary

InnateDB Gene

IDBG-26260.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGAL

Gene Name

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

Synonyms

CD11A; LFA-1; LFA1A

Species

Homo sapiens

Ensembl Gene

ENSG00000005844

Encoded Proteins

IDBP-26262

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

IDBP-26264

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

IDBP-375288

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

IDBP-751027

IDBP-751683

IDBP-748991

IDBP-746348

IDBP-751728

IDBP-747964

IDBP-753711

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:30472658-30523185

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000356798	ENSP00000349252
ENST00000358164	ENSP00000350886
ENST00000433423	ENSP00000409377
ENST00000564632
ENST00000565348
ENST00000564118	ENSP00000456888
ENST00000568012
ENST00000569725	ENSP00000461006
ENST00000563615	ENSP00000458739
ENST00000568987
ENST00000568926	ENSP00000457785
ENST00000562857	ENSP00000454342
ENST00000562652	ENSP00000456521
ENST00000564935
ENST00000566149
ENST00000565864	ENSP00000454908
ENST00000569570
ENST00000562020
ENST00000566267

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0016337	single organismal cell-cell adhesion
GO:0022407	regulation of cell-cell adhesion
GO:0022409	positive regulation of cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0042102	positive regulation of T cell proliferation
GO:0050776	regulation of immune response
GO:0050798	activated T cell proliferation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050900	leukocyte migration

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030830

View Gene Order

ENSBTAG00000007103

Not yet available

Pathways

NETPATH

REACTOME

REACT_11152

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_13552

Integrin cell surface interactions pathway

REACT_118779

Extracellular matrix organization pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_604

Hemostasis pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04650

Natural killer cell mediated cytotoxicity pathway

hsa05416

Viral myocarditis pathway

hsa05150

Staphylococcus aureus infection pathway

hsa05144

Malaria pathway

INOH

INOH website

Integrin signaling pathway pathway

PID NCI

integrin_cs_pathway

Integrin family cell surface interactions

integrin2_pathway

Beta2 integrin cell surface interactions

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.174103

RefSeq

NM_001114380 NM_002209 XM_005255313 XM_006721044

HUGO

OMIM

CCDS

CCDS32433 CCDS45461

HPRD

01079

IMGT

EMBL

GenPept

RNA Seq Atlas