Version 5.4
| Mus musculus Protein: Pltp | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-262648.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Pltp | ||||||||
| Protein Name | phospholipid transfer protein | ||||||||
| Synonyms | Bpife; OD107; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000104939 | ||||||||
| InnateDB Gene | IDBG-212419 (Pltp) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Highest in lung, adipose tissue, brain, and heart. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:103151 | ||||||||
| InterPro |
IPR001124
Lipid-binding serum glycoprotein, C-terminal IPR017942 Lipid-binding serum glycoprotein, N-terminal IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain |
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| PFAM |
PF02886
PF01273 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00329
SM00328 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P55065 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | Q3UFS5 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 18830 | ||||||||
| UniGene | Mm.6105 | ||||||||
| RefSeq | |||||||||
| MGI ID | |||||||||
| MGI Symbol | Pltp | ||||||||
| OMIM | |||||||||
| CCDS | CCDS17063 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK148330 AK149730 AL591495 BC003782 CH466551 U28960 U37226 | ||||||||
| GenPept | AAA80542 AAA87943 AAH03782 BAE28485 BAE29052 EDL06430 | ||||||||