InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc35c2

Summary

InnateDB Protein

IDBP-262688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc35c2

Protein Name

solute carrier family 35, member C2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104921

InnateDB Gene

IDBG-212587 (Slc35c2)

Protein Structure

UniProt Annotation

Function

May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006810	transport
GO:0010629	negative regulation of gene expression
GO:0036065	fucosylation
GO:0036066	protein O-linked fucosylation
GO:0045747	positive regulation of Notch signaling pathway
GO:0055085	transmembrane transport