InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map3k1

Summary

InnateDB Protein

IDBP-262769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k1

Protein Name

mitogen-activated protein kinase kinase kinase 1

Synonyms

MAPKKK1; Mekk; MEKK1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104890

InnateDB Gene

IDBG-182342 (Map3k1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 134 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	103 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	134 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0008545	JUN kinase kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0003382	epithelial cell morphogenesis
GO:0006468	protein phosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0008637	apoptotic mitochondrial changes
GO:0030334	regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0042060	wound healing
GO:0043010	camera-type eye development
GO:0045087	innate immune response (InnateDB)
GO:0061029	eyelid development in camera-type eye
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1346872

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001841 Zinc finger, RING-type
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR007527 Zinc finger, SWIM-type
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF13639
PF14634
PF04434

PRINTS

PR00109

PIRSF

SMART

SM00184
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt