InnateDB Protein
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IDBP-262799.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Prex1
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Protein Name
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phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000104869
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InnateDB Gene
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IDBG-212885 (Prex1)
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Protein Structure
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Function |
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005089
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Rho guanyl-nucleotide exchange factor activity
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GO:0005543
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phospholipid binding
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Biological Process |
GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0030217
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T cell differentiation
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GO:0030593
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neutrophil chemotaxis
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GO:0030833
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regulation of actin filament polymerization
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GO:0032855
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positive regulation of Rac GTPase activity
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GO:0035556
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intracellular signal transduction
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GO:0045785
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positive regulation of cell adhesion
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GO:0050773
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regulation of dendrite development
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GO:0072593
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reactive oxygen species metabolic process
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GO:1900026
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positive regulation of substrate adhesion-dependent cell spreading
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Cellular Component |
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PDB ID |
MGI:3040696
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q69ZK0
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PhosphoSite |
PhosphoSite-Q69ZK0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
277360
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UniGene |
Mm.489669
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RefSeq |
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MGI ID |
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MGI Symbol |
Prex1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK090301
AK173168
AL591884
AL732357
BC057617
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GenPept |
AAH57617
BAC41161
BAD32446
CAM16778
CAM16779
CAM22699
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