InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2v1

Summary

InnateDB Protein

IDBP-262886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2v1

Protein Name

ubiquitin-conjugating enzyme E2 variant 1

Synonyms

0610011J09Rik; AI256840; CROC-1; CROC1; D7Bwg1382e; UEV-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104830

InnateDB Gene

IDBG-262884 (Ube2v1)

Protein Structure

UniProt Annotation

Function

Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation (By similarity). Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Excluded from the nucleolus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in heart, brain, liver, skeletal msucle, kidney and testis. Detected at lower levels in lung and spleen. {ECO:0000269PubMed:11406273}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016881	acid-amino acid ligase activity
GO:0031624	ubiquitin conjugating enzyme binding

Biological Process

GO:0042275	error-free postreplication DNA repair
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070534	protein K63-linked ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031371	ubiquitin conjugating enzyme complex
GO:0035370	UBC13-UEV1A complex
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome