InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aurka

Summary

InnateDB Protein

IDBP-263024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aurka

Protein Name

aurora kinase A

Synonyms

AIRK1; ARK-1; Ark1; AU019385; Aurora-A; AW539821; Ayk1; IAK; IAK1; Stk6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104767

InnateDB Gene

IDBG-213281 (Aurka)

Protein Structure

UniProt Annotation

Function

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. {ECO:0000269PubMed:19075002, ECO:0000269PubMed:19668197, ECO:0000269PubMed:20643351, ECO:0000269PubMed:9245792}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes on centrosomes in interphase cells and at each spindle pole in mitosis. Associates with both the pericentriolar material (PCM) and centrioles. Colocalized with SIRT2 at centrosome (By similarity). Detected at the neurite hillock in developing neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in embryonic neurons in dorsal root ganglia and brain cortex (at protein level). Highly expressed in testis, in about one third of the seminiferous tubules. Expression is restricted to specific spermatocytes nearing completion of prophase, with levels falling off on transition to elongated spermatids. Highly expressed in the ovary, expression in the oocyte starts around the transition to large growing follicle. Abundant expression is seen in the proliferating granulosa and thecal cells of the growing follicle, and in the young corpus luteum. Very weakly expressed in spleen and intestine. {ECO:0000269PubMed:19668197, ECO:0000269PubMed:9245792}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	84 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0035174	histone serine kinase activity

Biological Process

GO:0000212	meiotic spindle organization
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007052	mitotic spindle organization
GO:0007057	spindle assembly involved in female meiosis I
GO:0007067	mitotic nuclear division
GO:0007100	mitotic centrosome separation
GO:0007126	meiotic nuclear division
GO:0009948	anterior/posterior axis specification
GO:0031647	regulation of protein stability
GO:0032091	negative regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035404	histone-serine phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0043146	spindle stabilization
GO:0051297	centrosome organization
GO:0051642	centrosome localization
GO:0071539	protein localization to centrosome
GO:0090233	negative regulation of spindle checkpoint
GO:1900195	positive regulation of oocyte maturation
GO:1990138	neuron projection extension

Cellular Component

GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005876	spindle microtubule
GO:0031616	spindle pole centrosome
GO:0042585	germinal vesicle
GO:0043203	axon hillock
GO:0045120	pronucleus
GO:0048471	perinuclear region of cytoplasm
GO:0072686	mitotic spindle
GO:0072687	meiotic spindle

Protein Structure and Domains

PDB ID

MGI:894678

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt