InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aurka

Summary

InnateDB Gene

IDBG-213281.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aurka

Gene Name

aurora kinase A

Synonyms

AIRK1; ARK-1; Ark1; AU019385; Aurora-A; AW539821; Ayk1; IAK; IAK1; Stk6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027496

Encoded Proteins

IDBP-213283

aurora kinase A

IDBP-263022

aurora kinase A

IDBP-263024

aurora kinase A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087586:
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:172356190-172370535

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028997	ENSMUSP00000028997
ENSMUST00000109140	ENSMUSP00000104768
ENSMUST00000109139	ENSMUSP00000104767
ENSMUST00000128004
ENSMUST00000126107

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	84 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0035174	histone serine kinase activity

Biological Process

GO:0000212	meiotic spindle organization
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007052	mitotic spindle organization
GO:0007057	spindle assembly involved in female meiosis I
GO:0007067	mitotic nuclear division
GO:0007100	mitotic centrosome separation
GO:0007126	meiotic nuclear division
GO:0009948	anterior/posterior axis specification
GO:0031647	regulation of protein stability
GO:0032091	negative regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035404	histone-serine phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0043146	spindle stabilization
GO:0051297	centrosome organization
GO:0051642	centrosome localization
GO:0071539	protein localization to centrosome
GO:0090233	negative regulation of spindle checkpoint
GO:1900195	positive regulation of oocyte maturation
GO:1990138	neuron projection extension

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005876	spindle microtubule
GO:0015630	microtubule cytoskeleton
GO:0031616	spindle pole centrosome
GO:0042585	germinal vesicle
GO:0043203	axon hillock
GO:0045120	pronucleus
GO:0048471	perinuclear region of cytoplasm
GO:0072686	mitotic spindle
GO:0072687	meiotic spindle