Version 5.4
Mus musculus Protein: Lima1
Summary
InnateDB Protein IDBP-263256.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lima1
Protein Name LIM domain and actin binding 1
Synonyms Eplin;
Species Mus musculus
Ensembl Protein ENSMUSP00000104652
InnateDB Gene IDBG-183902 (Lima1)
Protein Structure
UniProt Annotation
Function Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton. Note=This cytoskeletal protein colocalizes with actin stress fibers.
Disease Associations
Tissue Specificity Isoform Alpha is highly expressed in embryos from day 7-11 and in adult spleen and lung. Isoform Beta expression is highest in adult kidney, testis, lung and liver, intermediate in heart, brain, spleen, skeletal muscle and low in embryos.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0008270 zinc ion binding
GO:0051015 actin filament binding
Biological Process
GO:0030835 negative regulation of actin filament depolymerization
GO:0031529 ruffle organization
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID MGI:1920992
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ERG0
PhosphoSite PhosphoSite-Q9ERG0
TrEMBL Q8CD09
UniProt Splice Variant
Entrez Gene 65970
UniGene Mm.471984
RefSeq NP_075550
MGI ID
MGI Symbol Lima1
OMIM
CCDS CCDS37206
HPRD
IMGT
EMBL AF307844 AF307845 AK031698 AK132314 AK167220 BC031490 CH466550
GenPept AAG31147 AAG31148 AAH31490 BAC27520 BAE21099 BAE39345 EDL04110

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca