Version 5.4
Mus musculus Gene: Lima1
Summary
InnateDB Gene IDBG-183902.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lima1
Gene Name LIM domain and actin binding 1
Synonyms Eplin
Species Mus musculus
Ensembl Gene ENSMUSG00000023022
Encoded Proteins
IDBP-183904
LIM domain and actin binding 1
IDBP-263256
LIM domain and actin binding 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000050405:
This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:99778470-99875428
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000073691 ENSMUSP00000073371
ENSMUST00000109024 ENSMUSP00000104652
ENSMUST00000172119
ENSMUST00000171450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0051015 actin filament binding
Biological Process
GO:0030835 negative regulation of actin filament depolymerization
GO:0031529 ruffle organization
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000050405
View Gene Order
ENSBTAG00000012342
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
Cross-References
SwissProt Q9ERG0
TrEMBL Q8CD09
UniProt Splice Variant
Entrez Gene 65970
UniGene Mm.33207 Mm.410041 Mm.471984
RefSeq NM_001113545 XM_006521244 XM_006521245 XM_006521247 NM_023063
OMIM
CCDS CCDS49729 CCDS37206
HPRD
IMGT
MGI ID MGI:1920992
MGI Symbol Lima1
EMBL AF307844 AF307845 AK031698 AK132314 AK167220 BC031490 CH466550
GenPept AAG31147 AAG31148 AAH31490 BAC27520 BAE21099 BAE39345 EDL04110
RNA Seq Atlas 65970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca