InnateDB Protein
|
IDBP-263578.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Tnip1
|
Protein Name
|
TNFAIP3 interacting protein 1
|
Synonyms
|
ABIN; ABIN-1; ABIN1; AU018810; Naf1; Nef; VAN;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000104514
|
InnateDB Gene
|
IDBG-174207 (Tnip1)
|
Protein Structure
|
|
Function |
Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti- inflammatory response of macrophages and positively regulates TLR- induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. {ECO:0000269PubMed:12586352, ECO:0000269PubMed:21606507, ECO:0000269PubMed:22011580}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Ubiquitous. Abundant in heart and skeletal muscle and expressed at lower levels in thymus, liver, kidney, brain and intestinal tract.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
|
Protein-Protein |
10
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
37 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0002755
|
MyD88-dependent toll-like receptor signaling pathway
|
GO:0006954
|
inflammatory response
|
GO:0007159
|
leukocyte cell-cell adhesion
|
GO:0008152
|
metabolic process
|
GO:0009101
|
glycoprotein biosynthetic process
|
GO:0043124
|
negative regulation of I-kappaB kinase/NF-kappaB signaling
|
GO:0045087
|
innate immune response (InnateDB)
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
GO:0050729
|
positive regulation of inflammatory response
|
GO:0070373
|
negative regulation of ERK1 and ERK2 cascade
|
GO:0085032
|
modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
|
|
Cellular Component |
|
PDB ID |
MGI:1926194
|
InterPro |
IPR016024
Armadillo-type fold
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9WUU8
|
PhosphoSite |
PhosphoSite-Q9WUU8
|
TrEMBL |
D3Z3B6
|
UniProt Splice Variant |
|
Entrez Gene |
57783
|
UniGene |
Mm.259671
|
RefSeq |
NP_001186205
|
MGI ID |
|
MGI Symbol |
Tnip1
|
OMIM |
|
CCDS |
CCDS56769
|
HPRD |
|
IMGT |
|
EMBL |
AJ242777
AJ242778
AL593846
AX011241
AY012159
BC008186
BC008665
|
GenPept |
AAG42155
AAH08186
AAH08665
CAB44239
CAB44240
CAC07546
|
|
|