InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnip1

Summary

InnateDB Protein

IDBP-263580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnip1

Protein Name

TNFAIP3 interacting protein 1

Synonyms

ABIN; ABIN-1; ABIN1; AU018810; Naf1; Nef; VAN;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104513

InnateDB Gene

IDBG-174207 (Tnip1)

Protein Structure

UniProt Annotation

Function

Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti- inflammatory response of macrophages and positively regulates TLR- induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. {ECO:0000269PubMed:12586352, ECO:0000269PubMed:21606507, ECO:0000269PubMed:22011580}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Abundant in heart and skeletal muscle and expressed at lower levels in thymus, liver, kidney, brain and intestinal tract.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005488	binding
GO:0005515	protein binding
GO:0031593	polyubiquitin binding
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0007159	leukocyte cell-cell adhesion
GO:0008152	metabolic process
GO:0009101	glycoprotein biosynthetic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050729	positive regulation of inflammatory response
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0085032	modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade