InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sparc

Summary

InnateDB Protein

IDBP-263642.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Sparc

Protein Name

secreted acidic cysteine rich glycoprotein

Synonyms

BM-40; ON;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104486

InnateDB Gene

IDBG-175174 (Sparc)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0007165	signal transduction
GO:0042127	regulation of cell proliferation
GO:0060348	bone development
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:98373

InterPro

IPR002350 Kazal domain
IPR003645 Follistatin-like, N-terminal
IPR015369 Follistatin/Osteonectin EGF domain
IPR019577 SPARC/Testican, calcium-binding domain

PFAM

PF00050
PF07648
PF09289
PF10591

PRINTS

PIRSF

SMART

SM00280
SM00274

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite