InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sparc

Summary

InnateDB Gene

IDBG-175174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sparc

Gene Name

secreted acidic cysteine rich glycoprotein

Synonyms

BM-40; ON

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018593

Encoded Proteins

IDBP-175176

secreted acidic cysteine rich glycoprotein

IDBP-263642

secreted acidic cysteine rich glycoprotein

IDBP-536988

secreted acidic cysteine rich glycoprotein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113140:
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:55394500-55420080

Strand

Reverse strand

Band

B1.3

Transcripts

ENSMUST00000018737	ENSMUSP00000018737
ENSMUST00000108858	ENSMUSP00000104486
ENSMUST00000123775
ENSMUST00000130642
ENSMUST00000141530	ENSMUSP00000119475
ENSMUST00000125787

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001503	ossification
GO:0007165	signal transduction
GO:0007507	heart development
GO:0009629	response to gravity
GO:0010288	response to lead ion
GO:0030324	lung development
GO:0032496	response to lipopolysaccharide
GO:0033591	response to L-ascorbic acid
GO:0034097	response to cytokine
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0043434	response to peptide hormone
GO:0045471	response to ethanol
GO:0046686	response to cadmium ion
GO:0048839	inner ear development
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0060348	bone development
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031012	extracellular matrix
GO:0031988	membrane-bounded vesicle