Version 5.4
Mus musculus Protein: Hand1
Summary
InnateDB Protein IDBP-263672.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Hand1
Protein Name heart and neural crest derivatives expressed transcript 1
Synonyms bHLHa27; eHAND; Ehand1; Hxt; Th1; Thing1;
Species Mus musculus
Ensembl Protein ENSMUSP00000104473
InnateDB Gene IDBG-175912 (Hand1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001829 trophectodermal cell differentiation
GO:0001947 heart looping
GO:0003144 embryonic heart tube formation
GO:0003218 cardiac left ventricle formation
GO:0003219 cardiac right ventricle formation
GO:0006366 transcription from RNA polymerase II promoter
GO:0007507 heart development
GO:0030154 cell differentiation
GO:0035050 embryonic heart tube development
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060411 cardiac septum morphogenesis
GO:0060485 mesenchyme development
GO:0060536 cartilage morphogenesis
GO:0060707 trophoblast giant cell differentiation
GO:0061371 determination of heart left/right asymmetry
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:103577
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5SQG0
UniProt Splice Variant
Entrez Gene 15110
UniGene Mm.4746
RefSeq
MGI ID
MGI Symbol Hand1
OMIM
CCDS
HPRD
IMGT
EMBL AL732587
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca