Version 5.4
Mus musculus Gene: Hand1
Summary
InnateDB Gene IDBG-175912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hand1
Gene Name heart and neural crest derivatives expressed transcript 1
Synonyms bHLHa27; eHAND; Ehand1; Hxt; Th1; Thing1
Species Mus musculus
Ensembl Gene ENSMUSG00000037335
Encoded Proteins
IDBP-175914
heart and neural crest derivatives expressed transcript 1
IDBP-263672
heart and neural crest derivatives expressed transcript 1
IDBP-540189
heart and neural crest derivatives expressed transcript 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113196:
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:57828705-57832818
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000036917 ENSMUSP00000046999
ENSMUST00000108845 ENSMUSP00000104473
ENSMUST00000160392 ENSMUSP00000124951
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001709 cell fate determination
GO:0001824 blastocyst development
GO:0001829 trophectodermal cell differentiation
GO:0001947 heart looping
GO:0003007 heart morphogenesis
GO:0003144 embryonic heart tube formation
GO:0003218 cardiac left ventricle formation
GO:0003219 cardiac right ventricle formation
GO:0006366 transcription from RNA polymerase II promoter
GO:0007507 heart development
GO:0030154 cell differentiation
GO:0035050 embryonic heart tube development
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060411 cardiac septum morphogenesis
GO:0060485 mesenchyme development
GO:0060536 cartilage morphogenesis
GO:0060707 trophoblast giant cell differentiation
GO:0061371 determination of heart left/right asymmetry
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113196
View Gene Order
ENSBTAG00000002335
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4746
RefSeq NM_008213
OMIM
CCDS CCDS24721
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca