InnateDB Protein
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IDBP-263677.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cnot8
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Protein Name
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CCR4-NOT transcription complex, subunit 8
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Synonyms
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1500015I04Rik; 1810022F04Rik; AA536816; AU015770; AU043059;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000104471
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InnateDB Gene
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IDBG-176044 (Cnot8)
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Protein Structure
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Function |
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269PubMed:22367759}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006417
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regulation of translation
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GO:0008284
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positive regulation of cell proliferation
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GO:0031047
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gene silencing by RNA
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GO:0043928
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exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
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GO:0090503
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RNA phosphodiester bond hydrolysis, exonucleolytic
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Cellular Component |
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PDB ID |
MGI:1916375
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InterPro |
IPR006941
Ribonuclease CAF1
IPR012337
Ribonuclease H-like domain
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PFAM |
PF04857
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D8X5
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PhosphoSite |
PhosphoSite-Q9D8X5
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TrEMBL |
A2AFQ7
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UniProt Splice Variant |
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Entrez Gene |
69125
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UniGene |
Mm.399658
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RefSeq |
XP_006534165
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MGI ID |
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MGI Symbol |
Cnot8
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OMIM |
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CCDS |
CCDS24722
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HPRD |
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IMGT |
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EMBL |
AK007581
AK075727
AK150757
AK153907
AL672182
BC004040
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GenPept |
AAH04040
BAB25119
BAC35913
BAE29826
BAE32248
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