Mus musculus Protein: Atf7
Summary
InnateDB Protein IDBP-263703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atf7
Protein Name activating transcription factor 7
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000104456
InnateDB Gene IDBG-189070 (Atf7)
Protein Structure
UniProt Annotation
Function Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}. Nucleus, nucleoplasm {ECO:0000250}. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear peiphery (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 4 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005654 nucleoplasm
GO:0034399 nuclear periphery
Protein Structure and Domains
PDB ID MGI:2443472
InterPro IPR004827 Basic-leucine zipper domain
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR016378 Transcription factor, cyclic AMP-dependent
PFAM PF00170
PF07716
PF00096
PRINTS
PIRSF PIRSF003153
SMART SM00338
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R0S1
PhosphoSite PhosphoSite-Q8R0S1
TrEMBL V9GXY2
UniProt Splice Variant
Entrez Gene 223922
UniGene
RefSeq NP_666177
MGI ID
MGI Symbol Atf7
OMIM
CCDS CCDS37230
HPRD
IMGT
EMBL AC123870 AC137156 AK155046 BC026483 CH466550
GenPept AAH26483 BAE33012 EDL03961