InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbx5

Summary

InnateDB Protein

IDBP-263741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbx5

Protein Name

chromobox homolog 5 (Drosophila HP1a)

Synonyms

2610029O15Rik; C75991; HP1; Hp1a; Hp1alpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104441

InnateDB Gene

IDBG-189469 (Cbx5)

Protein Structure

UniProt Annotation

Function

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	35 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	113 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0035064	methylated histone binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0070491	repressing transcription factor binding
GO:1990226	histone methyltransferase binding

Biological Process

GO:0045892

negative regulation of transcription, DNA-templated

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000776	kinetochore
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005720	nuclear heterochromatin
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0010369	chromocenter
GO:0016605	PML body
GO:0017053	transcriptional repressor complex
GO:0035097	histone methyltransferase complex