Mus musculus Protein: Myt1
Summary
InnateDB Protein IDBP-263844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myt1
Protein Name myelin transcription factor 1
Synonyms Nzf2; Nzf2a; Nzf2b; Nztf2;
Species Mus musculus
Ensembl Protein ENSMUSP00000104388
InnateDB Gene IDBG-214243 (Myt1)
Protein Structure
UniProt Annotation
Function Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is more predominant than isoform 2 at all stages of development and adulthood. Expressed in differentiated neurons especially at higher levels in newly generated ones. {ECO:0000269PubMed:12351189}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001158 enhancer sequence-specific DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007399 nervous system development
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1100535
InterPro IPR002515 Zinc finger, C2HC-type
IPR013681 Myelin transcription factor 1
PFAM PF01530
PF08474
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CFC2
PhosphoSite PhosphoSite-Q8CFC2
TrEMBL
UniProt Splice Variant
Entrez Gene 17932
UniGene Mm.458718
RefSeq NP_001165087
MGI ID 2MF8
MGI Symbol Myt1
OMIM
CCDS CCDS50857
HPRD
IMGT
EMBL AB082378 AB093267 AF004294 AL845173 BC063252
GenPept AAC53456 AAH63252 BAC16512 BAC41451 CAM20798 CAM20799