InnateDB Protein
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IDBP-263846.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Myt1
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Protein Name
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myelin transcription factor 1
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Synonyms
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Nzf2; Nzf2a; Nzf2b; Nztf2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000104387
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InnateDB Gene
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IDBG-214243 (Myt1)
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Protein Structure
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Function |
Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is more predominant than isoform 2 at all stages of development and adulthood. Expressed in differentiated neurons especially at higher levels in newly generated ones. {ECO:0000269PubMed:12351189}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1100535
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InterPro |
IPR002515
Zinc finger, C2HC-type
IPR013681
Myelin transcription factor 1
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PFAM |
PF01530
PF08474
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CFC2
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PhosphoSite |
PhosphoSite-Q8CFC2
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TrEMBL |
Q3UXY0
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UniProt Splice Variant |
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Entrez Gene |
17932
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UniGene |
Mm.458718
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RefSeq |
NP_032691
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MGI ID |
2MF8
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MGI Symbol |
Myt1
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OMIM |
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CCDS |
CCDS17223
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HPRD |
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IMGT |
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EMBL |
AB082378
AB093267
AF004294
AK135131
AL845173
BC063252
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GenPept |
AAC53456
AAH63252
BAC16512
BAC41451
BAE22433
CAM20798
CAM20799
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