InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADI1

Summary

InnateDB Protein

IDBP-26385.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADI1

Protein Name

acireductone dioxygenase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371525

InnateDB Gene

IDBG-26383 (ADI1)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. {ECO:0000255HAMAP- Rule:MF_03154, ECO:0000269PubMed:11602742, ECO:0000269PubMed:15938715}.

Subcellular Localization

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.

Disease Associations

Tissue Specificity

Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney. {ECO:0000269PubMed:11602742, ECO:0000269PubMed:14718544}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006595	polyamine metabolic process
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003313 AraC-type arabinose-binding/dimerisation domain
IPR004313 Acireductone dioxygenase ARD family
IPR011051 RmlC-like cupin domain
IPR013096 Cupin 2, conserved barrel

PFAM

PF02311
PF03079
PF07883

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BV57

PhosphoSite