InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epn2

Summary

InnateDB Protein

IDBP-263953.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epn2

Protein Name

epsin 2

Synonyms

9530051D10Rik; AA536924; Ibp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104353

InnateDB Gene

IDBG-183300 (Epn2)

Protein Structure

UniProt Annotation

Function

Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=In punctate structures throughout the cell and particularly concentrated in the region of the Golgi complex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005543	phospholipid binding
GO:0008289	lipid binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006897	endocytosis
GO:0007219	Notch signaling pathway
GO:0048568	embryonic organ development

Cellular Component

GO:0030128

clathrin coat of endocytic vesicle

Protein Structure and Domains

PDB ID

MGI:1333766

InterPro

IPR001026 Epsin domain, N-terminal
IPR003903 Ubiquitin interacting motif
IPR008942 ENTH/VHS
IPR011417 AP180 N-terminal homology (ANTH) domain
IPR013809 Epsin-like, N-terminal

PFAM

PF01417
PF02809
PF07651

PRINTS

PIRSF

SMART

SM00726
SM00273

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CHU3