InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myh3

Summary

InnateDB Protein

IDBP-264002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myh3

Protein Name

myosin, heavy polypeptide 3, skeletal muscle, embryonic

Synonyms

MyHC-emb; Myhs-e; Myhse;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104329

InnateDB Gene

IDBG-187090 (Myh3)

Protein Structure

UniProt Annotation

Function

Muscle contraction.

Subcellular Localization

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0051015	actin filament binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0006200	ATP catabolic process
GO:0008152	metabolic process

Cellular Component

GO:0016459	myosin complex
GO:0030016	myofibril
GO:0032982	myosin filament
GO:0043292	contractile fiber
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1339709

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000533 Tropomyosin
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR009053 Prefoldin
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00261
PF12718
PF00063
PF01576
PF02736

PRINTS

PR00194
PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt