InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lair1

Summary

InnateDB Protein

IDBP-264190.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lair1

Protein Name

leukocyte-associated Ig-like receptor 1

Synonyms

5133400O11Rik; BB115266; D7Bwg0421e; Lair-1; mLair-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104241

InnateDB Gene

IDBG-137073 (Lair1)

Protein Structure

UniProt Annotation

Function

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in lymphoid organs and in cell lines of hemopoietic origin. {ECO:0000269PubMed:15100296}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0045087

innate immune response (InnateDB)

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:105492

InterPro

IPR007110 Immunoglobulin-like domain

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BG84

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

52855

UniGene

Mm.398105

RefSeq

MGI ID

4ETY

MGI Symbol

Lair1

OMIM

CCDS

HPRD

IMGT

EMBL

AK017222 AK033472 AK038574 AK043664 AK044465 AK050281 AK054158 AY392763 AY392764 AY392765 AY392766 BC025901

GenPept

AAH25901 AAR32125 AAR32126 AAR32127 AAR32128 BAC25505 BAC28306 BAC30051 BAC31610 BAC31936 BAC34164 BAC35674