Version 5.4
| Mus musculus Protein: Gp6 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-264211.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Gp6 | ||||||
| Protein Name | glycoprotein 6 (platelet) | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000104231 | ||||||
| InnateDB Gene | IDBG-264209 (Gp6) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. {ECO:0000269PubMed:10961879, ECO:0000269PubMed:16139873, ECO:0000269PubMed:16254207}. | ||||||
| Subcellular Localization | Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Megakaryocytes and platelets. {ECO:0000269PubMed:10961879}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:1889810 | ||||||
| InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR013151 Immunoglobulin |
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| PFAM |
PF00047
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00408
SM00409 |
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | P0C191 | ||||||
| PhosphoSite | PhosphoSite- | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 243816 | ||||||
| UniGene | Mm.248662 | ||||||
| RefSeq | NP_001156486 | ||||||
| MGI ID | |||||||
| MGI Symbol | Gp6 | ||||||
| OMIM | |||||||
| CCDS | CCDS51972 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AC137969 | ||||||
| GenPept | |||||||