Version 5.4
Mus musculus Gene: Gp6
Summary
InnateDB Gene IDBG-264209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gp6
Gene Name glycoprotein 6 (platelet)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000078810
Encoded Proteins
IDBP-264211
glycoprotein 6 (platelet)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088053:
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:4368713-4397744
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000108590 ENSMUSP00000104231
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0007596 blood coagulation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000088053
View Gene Order
ENSBTAG00000047175
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_225107
Platelet Adhesion to exposed collagen pathway
REACT_220092
GPVI-mediated activation cascade pathway
KEGG
mmu04512
ECM-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04512
ECM-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt P0C191
TrEMBL
UniProt Splice Variant
Entrez Gene 243816
UniGene Mm.248662
RefSeq NM_001163014
OMIM
CCDS CCDS51972
HPRD
IMGT
MGI ID MGI:1889810
MGI Symbol Gp6
EMBL AC137969
GenPept
RNA Seq Atlas 243816

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca