InnateDB Protein
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IDBP-264333.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Scimp
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Protein Name
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RIKEN cDNA A430084P05 gene
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000104174
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InnateDB Gene
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IDBG-195523 (Scimp)
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Protein Structure
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Function |
Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex class II (MHC-II) signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Together with MHC-II, associates with lipid- enriched microdomains called tetraspanin-enriched microdomains (TEMs). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) and T- cells (By similarity). Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod. Present at regions of cell-cell contacts but also at the leading edge of migrating cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in peripheral blood leukocytes (PBLs) (at protein level). Strongly expressed in the spleen and lymph nodes and weakly in other tissues of the immune system, including bone marrow, peripheral blood leukocytes (PBLs) and thymus. Not detected in the majority of nonimmune tissues, with the exception of lung. Expressed in antigen-presenting cells. {ECO:0000269PubMed:21930792}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0070374
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positive regulation of ERK1 and ERK2 cascade
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Cellular Component |
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PDB ID |
MGI:3610314
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3UU41
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PhosphoSite |
PhosphoSite-Q3UU41
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
327957
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UniGene |
Mm.164325
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RefSeq |
NP_001038991
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MGI ID |
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MGI Symbol |
Scimp
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OMIM |
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CCDS |
CCDS24967
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HPRD |
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IMGT |
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EMBL |
AK138818
AL596117
BC147177
BC147178
CR933735
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GenPept |
AAI47178
AAI47179
BAE23788
CAI25187
CAM28154
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