Version 5.4
Mus musculus Protein: Derl2
Summary
InnateDB Protein IDBP-264349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Derl2
Protein Name Der1-like domain family, member 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000104163
InnateDB Gene IDBG-195837 (Derl2)
Protein Structure
UniProt Annotation
Function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed, with lowest levels in brain and heart. {ECO:0000269PubMed:11500051, ECO:0000269PubMed:16186509}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0001967 suckling behavior
GO:0008284 positive regulation of cell proliferation
GO:0030307 positive regulation of cell growth
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0030970 retrograde protein transport, ER to cytosol
Cellular Component
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:2151483
InterPro IPR007599 Derlin
PFAM PF04511
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BNI4
PhosphoSite PhosphoSite-Q8BNI4
TrEMBL
UniProt Splice Variant
Entrez Gene 116891
UniGene Mm.470408
RefSeq
MGI ID
MGI Symbol Derl2
OMIM
CCDS
HPRD
IMGT
EMBL AF208064 AK048627 AK077659 AK082564 AK083632 BC005682
GenPept AAH05682 AAL14868 BAC33399 BAC36934 BAC38533 BAC38974

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca