InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTT2B

Summary

InnateDB Protein

IDBP-2644.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTT2B

Protein Name

glutathione S-transferase theta 2B (gene/pseudogene)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000290765

InnateDB Gene

IDBG-2642 (GSTT2B)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells. {ECO:0000269PubMed:8761485}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0044281	small molecule metabolic process
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM