InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hif3a

Summary

InnateDB Protein

IDBP-264424.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Hif3a

Protein Name

hypoxia inducible factor 3, alpha subunit

Synonyms

bHLHe17; Ipas; MOP7; NEPAS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104132

InnateDB Gene

IDBG-147492 (Hif3a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1859778

InterPro

IPR000014 PAS domain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold
IPR021537 Hypoxia-inducible factor, alpha subunit

PFAM

PF13188
PF13426
PF00010
PF08447
PF00989
PF11413

PRINTS

PIRSF

SMART

SM00091
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite