InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apoc1

Summary

InnateDB Protein

IDBP-264507.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apoc1

Protein Name

apolipoprotein C-I

Synonyms

apo-CI; Apo-CIB; apoC-I; ApoC-IB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104091

InnateDB Gene

IDBG-152061 (Apoc1)

Protein Structure

UniProt Annotation

Function

Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. {ECO:0000269PubMed:17339654}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005504	fatty acid binding
GO:0055102	lipase inhibitor activity

Biological Process

GO:0006641	triglyceride metabolic process
GO:0008203	cholesterol metabolic process
GO:0010900	negative regulation of phosphatidylcholine catabolic process
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0032375	negative regulation of cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034369	plasma lipoprotein particle remodeling
GO:0034382	chylomicron remnant clearance
GO:0034447	very-low-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0050995	negative regulation of lipid catabolic process
GO:0051005	negative regulation of lipoprotein lipase activity

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0070062	extracellular vesicular exosome