InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serpinf2

Summary

InnateDB Protein

IDBP-264538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinf2

Protein Name

serine (or cysteine) peptidase inhibitor, clade F, member 2

Synonyms

AI747498; Pli; Serpimf2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104076

InnateDB Gene

IDBG-199917 (Serpinf2)

Protein Structure

UniProt Annotation

Function

Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed by the liver and secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0002034	regulation of blood vessel size by renin-angiotensin
GO:0006953	acute-phase response
GO:0010033	response to organic substance
GO:0010757	negative regulation of plasminogen activation
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030199	collagen fibril organization
GO:0032967	positive regulation of collagen biosynthetic process
GO:0045597	positive regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0048514	blood vessel morphogenesis
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051496	positive regulation of stress fiber assembly
GO:0051918	negative regulation of fibrinolysis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071636	positive regulation of transforming growth factor beta production