InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Serpinf2

Summary

InnateDB Gene

IDBG-199917.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinf2

Gene Name

serine (or cysteine) peptidase inhibitor, clade F, member 2

Synonyms

AI747498; Pli; Serpimf2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038224

Encoded Proteins

IDBP-199919

serine (or cysteine) peptidase inhibitor, clade F, member 2

IDBP-264538

serine (or cysteine) peptidase inhibitor, clade F, member 2

IDBP-539307

serine (or cysteine) peptidase inhibitor, clade F, member 2

IDBP-534081

serine (or cysteine) peptidase inhibitor, clade F, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167711:
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:75431732-75439591

Strand

Reverse strand

Band

Transcripts

ENSMUST00000043696	ENSMUSP00000048704
ENSMUST00000108437	ENSMUSP00000104076
ENSMUST00000128330	ENSMUSP00000114450
ENSMUST00000142094	ENSMUSP00000120812

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002034	regulation of blood vessel size by renin-angiotensin
GO:0006953	acute-phase response
GO:0010033	response to organic substance
GO:0010757	negative regulation of plasminogen activation
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030199	collagen fibril organization
GO:0032967	positive regulation of collagen biosynthetic process
GO:0045597	positive regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0048514	blood vessel morphogenesis
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051496	positive regulation of stress fiber assembly
GO:0051918	negative regulation of fibrinolysis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071636	positive regulation of transforming growth factor beta production