InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo18a

Summary

InnateDB Protein

IDBP-264649.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo18a

Protein Name

myosin XVIIIA

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104012

InnateDB Gene

IDBG-201810 (Myo18a)

Protein Structure

UniProt Annotation

Function

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. {ECO:0000269PubMed:19837035}.

Subcellular Localization

Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm, cytoskeleton. Note=Colocalizes with actin.Isoform 2: Cytoplasm. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm.Golgi apparatus {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Recruited to the Golgi apparatus by GOLPH3. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed ubiquitously. Isoform 2 is specifically expressed in most hematopoietic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0043531	ADP binding
GO:0051015	actin filament binding

Biological Process

GO:0007030	Golgi organization
GO:0008152	metabolic process
GO:0016477	cell migration
GO:0031032	actomyosin structure organization
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0048194	Golgi vesicle budding
GO:0050714	positive regulation of protein secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005802	trans-Golgi network
GO:0005856	cytoskeleton
GO:0016459	myosin complex
GO:0042641	actomyosin

Protein Structure and Domains

PDB ID

MGI:2667185

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001478 PDZ domain
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR016137 Regulator of G protein signalling superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00595
PF13180
PF00063
PF01576

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00228
SM00242
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt