Version 5.4
Mus musculus Protein: Prx
Summary
InnateDB Protein IDBP-264714.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prx
Protein Name periaxin
Synonyms L-Periaxin;
Species Mus musculus
Ensembl Protein ENSMUSP00000103992
InnateDB Gene IDBG-161168 (Prx)
Protein Structure
UniProt Annotation
Function Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition.
Subcellular Localization Nucleus {ECO:0000269PubMed:10671475}.Isoform 1: Cell membrane. Note=Associated with plasma membrane during myelination.Isoform 2: Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:108176
InterPro IPR001478 PDZ domain
PFAM PF00595
PF13180
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O55103
PhosphoSite PhosphoSite-O55103
TrEMBL
UniProt Splice Variant
Entrez Gene 19153
UniGene Mm.10119
RefSeq NP_062285
MGI ID
MGI Symbol Prx
OMIM
CCDS CCDS39849
HPRD
IMGT
EMBL AJ222968 AJ222969
GenPept CAA11022 CAA11023

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca