InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gem

Summary

InnateDB Protein

IDBP-264826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gem

Protein Name

GTP binding protein (gene overexpressed in skeletal muscle)

Synonyms

AV020497;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103939

InnateDB Gene

IDBG-129655 (Gem)

Protein Structure

UniProt Annotation

Function

Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0019003	GDP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0015684	ferrous iron transport
GO:0051276	chromosome organization
GO:0051310	metaphase plate congression

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0009898	cytoplasmic side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030496	midbody
GO:0051233	spindle midzone
GO:0072686	mitotic spindle

Protein Structure and Domains

PDB ID

MGI:99844

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR013684 Mitochondrial Rho-like
IPR017358 Small GTPase superfamily, GEM/REM/Rad
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF02421
PF08477

PRINTS

PR00449

PIRSF

PIRSF038017

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References