Version 5.4
Mus musculus Gene: Gem
Summary
InnateDB Gene IDBG-129655.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gem
Gene Name GTP binding protein (gene overexpressed in skeletal muscle)
Synonyms AV020497
Species Mus musculus
Ensembl Gene ENSMUSG00000028214
Encoded Proteins
IDBP-129657
GTP binding protein (gene overexpressed in skeletal muscle)
IDBP-264826
GTP binding protein (gene overexpressed in skeletal muscle)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164949:
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:11704457-11714752
Strand Forward strand
Band A1
Transcripts
ENSMUST00000029868 ENSMUSP00000029868
ENSMUST00000108304 ENSMUSP00000103939
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0015093 ferrous iron transmembrane transporter activity
GO:0019003 GDP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0015684 ferrous iron transport
GO:0051276 chromosome organization
GO:0051310 metaphase plate congression
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030496 midbody
GO:0051233 spindle midzone
GO:0072686 mitotic spindle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164949
View Gene Order
ENSBTAG00000007596
Not yet available
Cross-References
SwissProt P55041
TrEMBL Q3TH76
UniProt Splice Variant
Entrez Gene 14579
UniGene Mm.247486 Mm.471452
RefSeq NM_010276
OMIM
CCDS CCDS17971
HPRD
IMGT
MGI ID MGI:99844
MGI Symbol Gem
EMBL AK158393 AK168401 AK171336 BC029668 CH466538 U10551 U13053
GenPept AAA64912 AAC52145 AAH29668 BAE34484 BAE40322 BAE42399 EDL05640
RNA Seq Atlas 14579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca