InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF5

Summary

InnateDB Protein

IDBP-26503.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF5

Protein Name

fibroblast growth factor 5

Synonyms

HBGF-5; Smag-82; TCMGLY;

Species

Homo sapiens

Ensembl Protein

ENSP00000311697

InnateDB Gene

IDBG-26501 (FGF5)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in neonatal brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010001	glial cell differentiation
GO:0023019	signal transduction involved in regulation of gene expression
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051781	positive regulation of cell division