InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGF5

Summary

InnateDB Gene

IDBG-26501.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF5

Gene Name

fibroblast growth factor 5

Synonyms

HBGF-5; Smag-82; TCMGLY

Species

Homo sapiens

Ensembl Gene

ENSG00000138675

Encoded Proteins

IDBP-26503

fibroblast growth factor 5

IDBP-372503

fibroblast growth factor 5

IDBP-476568

fibroblast growth factor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:80266599-80336680

Strand

Forward strand

Band

q21.21

Transcripts

ENST00000312465	ENSP00000311697
ENST00000380628
ENST00000456523	ENSP00000398353
ENST00000507780	ENSP00000423903
ENST00000503413

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010001	glial cell differentiation
GO:0023019	signal transduction involved in regulation of gene expression
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051781	positive regulation of cell division

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029337

View Gene Order

ENSBTAG00000017348

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04010

MAPK signaling pathway pathway

hsa05218

Melanoma pathway

hsa05200

Pathways in cancer pathway

INOH

INOH website

FGF signaling pathway pathway

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

P12034

TrEMBL

UniProt Splice Variant

Entrez Gene

2250

UniGene

RefSeq

NM_001291812 NM_033143 NM_004464

HUGO

HGNC:3683

OMIM

165190

CCDS

CCDS3586 CCDS34021

HPRD

01307

IMGT

EMBL

AB016517 AF171928 AF535149 AK291962 AK312065 BC074858 BC074859 BC131502 CH471057 DQ151636 M23534 M23535 M23536 M37825

GenPept

AAB06463 AAB60698 AAB60699 AAF89742 AAH74858 AAH74859 AAI31503 AAN04097 AAZ67914 BAA33738 BAF84651 BAG35001 EAX05859 EAX05860

RNA Seq Atlas

2250