InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epha7

Summary

InnateDB Protein

IDBP-265051.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Epha7

Protein Name

Eph receptor A7

Synonyms

Cek11; Ebk; Ehk3; Hek11; Mdk1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103826

InnateDB Gene

IDBG-132772 (Epha7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0045499	chemorepellent activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0031290	retinal ganglion cell axon guidance
GO:0043525	positive regulation of neuron apoptotic process
GO:0048013	ephrin receptor signaling pathway
GO:0048755	branching morphogenesis of a nerve
GO:0050919	negative chemotaxis

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

MGI:95276

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM