InnateDB Protein
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IDBP-265156.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Orc3
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Protein Name
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origin recognition complex, subunit 3
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Synonyms
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Orc3l;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103777
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InnateDB Gene
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IDBG-134938 (Orc3)
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Protein Structure
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Function |
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
31 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
GO:0005664
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nuclear origin of replication recognition complex
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PDB ID |
MGI:1354944
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InterPro |
IPR020795
Origin recognition complex, subunit 3
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PFAM |
PF07034
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JK30
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PhosphoSite |
PhosphoSite-Q9JK30
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
50793
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UniGene |
Mm.399624
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RefSeq |
NP_001153035
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MGI ID |
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MGI Symbol |
Orc3
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OMIM |
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CCDS |
CCDS51137
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HPRD |
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IMGT |
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EMBL |
AB190257
AJ132830
AK045388
AK086579
AL807397
AL928738
BC061252
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GenPept |
AAH61252
BAC32339
BAC39695
BAD91665
CAB76399
CAM16474
CAM16475
CAM26869
CAM26870
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