InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il11ra1

Summary

InnateDB Protein

IDBP-265368.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il11ra1

Protein Name

interleukin 11 receptor, alpha chain 1

Synonyms

AI314697; GP130; Il-11ra; Il11ra; Il11ra2; NR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103677

InnateDB Gene

IDBG-138483 (Il11ra1)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.A soluble form (sIL11RA) can act as an antagonist of IL11-dependent cell differentiation in cells where both transmembrane IL11RA and IL6ST are present.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Widely expressed in all adult tissues and in embryos. Highest levels in kidney, skeletal muscle and embryo. {ECO:0000269PubMed:8662802}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004921	interleukin-11 receptor activity
GO:0005515	protein binding
GO:0019970	interleukin-11 binding

Biological Process

GO:0001779	natural killer cell differentiation
GO:0001890	placenta development
GO:0008284	positive regulation of cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0032502	developmental process
GO:0038154	interleukin-11-mediated signaling pathway
GO:0046697	decidualization
GO:0060135	maternal process involved in female pregnancy
GO:0060322	head development