InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il11ra1

Summary

InnateDB Gene

IDBG-138483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il11ra1

Gene Name

interleukin 11 receptor, alpha chain 1

Synonyms

AI314697; GP130; Il-11ra; Il11ra; Il11ra2; NR1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000073889

Encoded Proteins

IDBP-138485

interleukin 11 receptor, alpha chain 1

IDBP-265368

interleukin 11 receptor, alpha chain 1

IDBP-265370

interleukin 11 receptor, alpha chain 1

IDBP-265372

interleukin 11 receptor, alpha chain 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137070:
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:41699989-41769474

Strand

Forward strand

Band

Transcripts

ENSMUST00000098132	ENSMUSP00000095736
ENSMUST00000108042	ENSMUSP00000103677
ENSMUST00000108041	ENSMUSP00000103676
ENSMUST00000108040	ENSMUSP00000103675
ENSMUST00000146608
ENSMUST00000140894
ENSMUST00000145445
ENSMUST00000155538
ENSMUST00000152748
ENSMUST00000142059

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004921	interleukin-11 receptor activity
GO:0005515	protein binding
GO:0019970	interleukin-11 binding

Biological Process

GO:0001779	natural killer cell differentiation
GO:0001890	placenta development
GO:0008284	positive regulation of cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0032502	developmental process
GO:0038154	interleukin-11-mediated signaling pathway
GO:0046697	decidualization
GO:0060135	maternal process involved in female pregnancy
GO:0060322	head development

Cellular Component

GO:0016021

integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000137070

View Gene Order

ENSBTAG00000014907

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu04630

Jak-STAT signaling pathway pathway

mmu04640

Hematopoietic cell lineage pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_147

IL11 pathway

REACTOME

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.193451 Mm.476981

RefSeq

NM_001163401 NM_001172054 NM_010549 XM_006537622

OMIM

CCDS

CCDS18071

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas